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Authored by Rich Harris, Svelte takes a unique approach. It compiles your app at build time so that you ship the lightest weight code possible. From the documentation:

...Svelte has a crucial difference: rather than interpreting your application code at run time, your app is converted into ideal JavaScript at build time. That means you don't pay the performance cost of the framework's abstractions, or incur a penalty when your app first loads.

And because there's no overhead, you can easily adopt Svelte in an existing app incrementally, or ship widgets as standalone packages that work anywhere.

An interesting project related to Svelte is Betula Rock Unisex Adults ggxym
, a framework similar in philosophy to Next.js , but with a greater emphasis on performance.

Sapper is a framework for building extremely high-performance web apps...There are two basic concepts:

Building an app with all the modern best practices — code-splitting, offline support, server-rendered views with client-side hydration — is fiendishly complicated. Sapper does all the boring stuff for you so that you can get on with the creative part.

There are a lot of interesting frameworks here. Some are the product of a single developer, while others have strong communities with a large number of contributors and corporate sponsorship.

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in a small (3KB) library that uses TypeScript as the development language and takes inspiration from Elm:

Binding.scala is a one-way data-binding library written in Scala, although it targets both JavaScript and JVM. From the Vagabond Bonnie Wedges Black m9C78zL8
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Bobril takes inspiration from React and Womens Elegant Pointed Toe Shallow Mouth Stiletto High Heel Pumps Shoes Yellow Patent PU 1k1XnWkCu
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It is fast, low size framework with rendering based on Virtual DOM. The main focus is on speed and simplicity of code generation...Content and behavior of any page can be defined simply by composing JavaScript objects.

The page content rendering is based on comparison of Virtual DOMs. The application has some state in time and bobril application generates the Virtual DOM according to this state. Virtual DOM is an object representation of the resultant DOM. If some state-changing event occurs and the previous Virtual DOM is different than currently generated Virtual DOM, the real DOM will change according to this change.

is a functional library for building user interfaces. It's small (4KB) and supports server rendering. The Choo philosophy:

We believe frameworks should be disposable, and components recyclable. We don't want a web where walled gardens jealously compete with one another. By making the DOM the lowest common denominator, switching from one framework to another becomes frictionless. Choo is modest in its design; we don't believe it will be top of the class forever, so we've made it as easy to toss out as it is to pick up...We want everyone on a team, no matter the size, to fully understand how an application is laid out. And once an application is built, we want it to be small, performant and easy to reason about. All of which makes for easy to debug code, better results and super smiley faces.

European Reference Network on Rare Endocrine Conditions

What are ERNs?

European Reference Networks (ERN) are virtual networks involving Reference Centers across Europe. They aim to tackle complex or rare medical diseases or conditions that require highly specialised treatment and a concentration of knowledge and resources.

The European Reference Network on rare endocrine conditions (Endo-ERN) aims to improve access to high-quality healthcare for patients with hormonal disorders. Endocrine conditions are often complex and require a long period of care due to chronic disease without being life-threatening. Therefore, endocrine care requires equal distribution of paediatric and adult care.

Endo-ERN aims to provide this care for patients throughout their entire lives and to reduce and ultimately abolish inequalities in care for patients with rare endocrine disorders in Europe, through facilitating knowledge sharing and facilitating related healthcare and research.

More information on Endo-ERN
What are ERNs?

Read the Endo-ERN May newsletter now! In this edition we announce our presence at the European Society for Paediatric Endocrinology meeting, you can read reports[...]

The 2nd workshop for multidisciplinary teams caring for pituitary tumours, CAPITAL, was held on June 7 and 8, in Leiden, The Netherlands and was a[...]

The fourth Italian Endo-ERN meeting took place on the 7th of June, in Padova, Italy. The aim of the meeting, organised by the Italian national[...]

The next Endo-ERN Steering Committee Advisory Board meeting will take place on Friday September 28th, from 16:30-18:30 hrs, at the Annual European Society of[...]

September 27 - September 29, 2018
September 28, 2018
December 1 - December 4, 2018
January 14 - January 18, 2019
March 12, 2019

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Have you read the recently translated into English version of the quality of care standard for #adrenal disorders b… twitter.com/i/web/status/1…

@RareEndoERN

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Travel whenever you can. Don’t worry about the costs, try your best to make it work. Experience is far more valuable than money will ever be!

Would you like to travel but your bank account seems to disagree? Don’t worry! Nowadays, travelling is accessible to anyone, even to students who suffer from a lack of finances. By following these tips, you can save money and get an even more interesting experience.

Our generation is lucky. Travelling is easier, cheaper, and more convenient, especially for Europeans since Europe is rather small, mostly without borders and there are various means of transport at our disposal. The fastest way is still by plane. It’s worth mentioning one of the best known low-cost airlines, Ryanair, which has a broad web of lines around Europe and beyond. The same could be said, for instance, about EasyJet, Vueling, and Wizz Air, too. So flying with these airlines could be a great beginning to your adventure.

However, there are also tricks on how to save money by travelling by road. One of the alternatives to traditional buses and trains is Mens Shoes Feifei Winter Fashion Casual Leather Shoes 4 Colors Color 03 Size EU/41/UK758/CN42 5qZLyfYiiu
. It’s a service where you carpool with local drivers. It is much cheaper and, in addition, you can share stories and ask for advice on what is worth visiting and how to get there from locals who know the place the best. Furthermore, some countries have their own platforms so set some time aside for research.

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If you are brave enough, you can even move from one place to another for free by hitchhiking. This option is recommended only in cases in which you travel in groups or pairs, for your own safety. In order to find a suitable spot where you’re most likely to be picked up, try Fashion Thirsty Men Women Kids Emoji Plush Stuffed Unisex Slipper Winter Home Indoor Shoes Size Brown / Poop Shape kgcQh7e6
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Another option is renting a car. If you travel in a group of more than 3 people, it’s a good option to move around with low costs.

Young people usually prefer hostels which are more affordable and places where they can meet people with similar mindsets. However, there are more interesting options when it comes to finding a roof over your head. For instance, an alternative to hostels could be TAOFFEN Women Fashion Flats Slingback Sandals Black 6HwICM
. This is usually cheaper if you travel in a pair or a group of friends. You can rent a whole apartment or even a house only for yourselves.

Airbnb

On the other hand, for more adventurous travellers, there are few communities where you can find accommodation for free. Probably the best known is Couchsurfing . The only thing you have to do is create a profile and then you can search for potential hosts who can offer you a place to sleep. There are people from the entire world and it’s one of the best ways to meet local people and experience their lifestyle.

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